To treat an ankle sprain with physical therapy, begin with rest, ice, compression, and elevation (RICE) to reduce swelling and pain. Gradually introduce range-of-motion exercises, such as ankle circles and toe flexes, to restore flexibility. Progress to strengthening exercises like calf raises and resistance band movements to rebuild stability. Balance and proprioception exercises, like standing on one foot, help prevent re-injury. As mobility improves, return to weight-bearing activities and gradually increase intensity.